Consensus Definitions for Sepsis and Septic Shock from JAMA Network (2024)

Assessment of Health Care Exposures and Outcomes in Adult Patients With Sepsis and Septic Shock

Katherine Fay and Coauthors

JAMA Network Open | Original Investigation, July 7, 2020

Early-Onset Neonatal Sepsis 2015 to 2017, the Rise of Escherichia coli, and the Need for Novel Prevention Strategies

Barbara J. Stoll and Coauthors

JAMA Pediatrics | Original Investigation, May 4, 2020

Prevalence of Antibiotic-Resistant Pathogens in Culture-Proven Sepsis and Outcomes Associated With Inadequate and Broad-Spectrum Empiric Antibiotic Use

Chanu Rhee and Coauthors

JAMA Network Open | Original Investigation, April 16, 2020

Association of a Care Bundle for Early Sepsis Management With Mortality Among Patients With Hospital-Onset or Community-Onset Sepsis

Jonathan D. Baghdadi and Coauthors

JAMA Internal Medicine | Original Investigation, April 6, 2020

How Effective Is the Early Management Bundle for Severe Sepsis/Septic Shock?

Hannah Moreira and Richard Sinert

JAMA Internal Medicine | Invited Commentary, April 6, 2020

Risk Factors for Long-term Mortality and Patterns of End-of-Life Care Among Medicare Sepsis Survivors Discharged to Home Health Care

Katherine R. Courtright and Coauthors

JAMA Network Open | Original Investigation, February 26, 2020

Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial

François Lamontagne and Coauthors

JAMA | Original Investigation, February 12, 2020

Evaluation of the Coverage of 3 Antibiotic Regimens for Neonatal Sepsis in the Hospital Setting Across Asian Countries

Julia A. Bielicki and Coauthors

JAMA Network Open | Original Investigation, February 12, 2020

Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia: A Randomized Clinical Trial

Steven Y. C. Tong and Coauthors

JAMA | Original Investigation, February 11, 2020

C-Reactive Protein Testing in Late-Onset Neonatal Sepsis: Hazardous Waste

Joseph B. Cantey and Charlene R. Bultmann

JAMA Pediatrics | Editorial, February 3, 2020

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial

Tomoko Fujii and Coauthors

JAMA | Preliminary Communication, January 17, 2020

Lack of Benefit of High-Dose Vitamin C, Thiamine, and Hydrocortisone Combination for Patients With Sepsis

Andre C. Kalil

JAMA | Editorial, January 17, 2020

Differences in Central Line–Associated Bloodstream Infection Rates Based on the Criteria Used to Count Central Line Days

David Scheinker and Coauthors

JAMA | Research Letter, January 14, 2020

Evaluation of Plasma Microbial Cell-Free DNA Sequencing to Predict Bloodstream Infection in Pediatric Patients With Relapsed or Refractory Cancer

Kathryn P. Goggin and Coauthors

JAMA Oncology | Brief Report, December 19, 2019

Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial

Pierre-Francois Laterre and Coauthors

JAMA | Original Investigation, October 2, 2019

Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial

Alpha A. Fowler III and Coauthors

JAMA | Preliminary Communication, October 1, 2019

Is High-Dose Vitamin C Beneficial for Patients With Sepsis?

Emily B. Brant and Derek C. Angus

JAMA | Editorial, October 1, 2019

Incidence of Maternal Sepsis and Sepsis-Related Maternal Deaths in the United States

Matthew K. Hensley and Coauthors

JAMA | Research Letter, September 3, 2019

Association of Use of the Neonatal Early-Onset Sepsis Calculator With Reduction in Antibiotic Therapy and Safety: A Systematic Review and Meta-analysis

Niek B. Achten and Coauthors

JAMA Pediatrics | Original Investigation, September 3, 2019

Neonatal Sepsis Evaluation: Facing the Certainty of Uncertainty

Karen M. Puopolo and Gabriel J. Escobar

JAMA Pediatrics | Editorial, September 3, 2019

Cost of Pediatric Severe Sepsis Hospitalizations

Erin F. Carlton and Coauthors

JAMA Pediatrics | Research Letter, August 12, 2019

Long-term Host Immune Response Trajectories Among Hospitalized Patients With Sepsis

Sachin Yende and Coauthors

JAMA Network Open | Original Investigation, August 7, 2019

Association Between State-Mandated Protocolized Sepsis Care and In-hospital Mortality Among Adults With Sepsis

Jeremy M. Kahn and Coauthors

JAMA | Original Investigation, July 16, 2019

Wide Interest in a Vitamin C Drug co*cktail for Sepsis Despite Lagging Evidence

Rita Rubin

JAMA | Medical News & Perspectives, July 3, 2019

Risk Factors at Index Hospitalization Associated With Longer-term Mortality in Adult Sepsis Survivors

Manu Shankar-Hari and Coauthors

JAMA Network Open | Original Investigation, May 31, 2019

Recombinant Human Soluble Thrombomodulin in Patients With Sepsis-Associated Coagulopathy: Another Negative Sepsis Trial?

Tom van der Poll

JAMA | Editorial, May 19, 2019

New Phenotypes for Sepsis: The Promise and Problem of Applying Machine Learning and Artificial Intelligence in Clinical Research

William A. Knaus and Richard D. Marks

JAMA | Editorial, May 19, 2019

Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial

Jean-Louis Vincent and Coauthors

JAMA | Original Investigation, May 19, 2019

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

Christopher W. Seymour and Coauthors

JAMA | Original Investigation, May 19, 2019

Prevalence of Bacteremia and Bacterial Meningitis in Febrile Neonates and Infants in the Second Month of Life: A Systematic Review and Meta-analysis

Eric A. Biondi and Coauthors

JAMA Network Open | Original Investigation, March 22, 2019

Reducing Collateral Damage From Mandates for Time to Antibiotics in Pediatric Sepsis—Primum Non Nocere

Luregn J. Schlapbach and Coauthors

JAMA Pediatrics | Viewpoint, March 18, 2019

Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial

Glenn Hernández and Coauthors

JAMA | Original Investigation, February 17, 2019

How Best to Resuscitate Patients With Septic Shock?

Derek C. Angus

JAMA | Editorial, February 17, 2019

Prevalence, Underlying Causes, and Preventability of Sepsis-Associated Mortality in US Acute Care Hospitals

Chanu Rhee and Coauthors

JAMA Network Open | Original Investigation, February 15, 2019

A Closer Look at Sepsis-Associated Mortality

Laura Evans

JAMA Network Open | Invited Commentary, February 15, 2019

Global Case-Fatality Rates in Pediatric Severe Sepsis and Septic Shock: A Systematic Review and Meta-analysis

Bobby Tan and Coauthors

JAMA Pediatrics | Original Investigation, February 11, 2019

Association of 30-Day Mortality With Oral Step-Down vs Continued Intravenous Therapy in Patients Hospitalized With Enterobacteriaceae Bacteremia

Pranita D. Tamma and Coauthors

JAMA Internal Medicine | Original Investigation, January 22, 2019

Effect of Levocarnitine vs Placebo as an Adjunctive Treatment for Septic Shock: The Rapid Administration of Carnitine in Sepsis (RACE) Randomized Clinical Trial

Alan E. Jones and Coauthors

JAMA Network Open | Original Investigation, December 21, 2018

Association of Corticosteroid Treatment With Outcomes in Adult Patients With Sepsis: A Systematic Review and Meta-analysis

Fang Fang and Coauthors

JAMA Internal Medicine | Original Investigation, December 21, 2018

Association Between Early Intravenous Fluids Provided by Paramedics and Subsequent In-Hospital Mortality Among Patients With Sepsis

Daniel J. Lane and Coauthors

JAMA Network Open | Original Investigation, December 14, 2018

Serum Creatinine in the Critically Ill Patient With Sepsis

Matthieu Legrand and John A. Kellum

JAMA | JAMA Diagnostic Test Interpretation, December 11, 2018

Artificial Intelligence Tools for Sepsis and Cancer

Jennifer Abbasi

JAMA | Biotech Innovations, December 11, 2018

Antibiotics for Sepsis—Finding the Equilibrium

Michael Klompas and Coauthors

JAMA | Viewpoint, September 14, 2018

Association of the Quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) Score With Excess Hospital Mortality in Adults With Suspected Infection in Low- and Middle-Income Countries

Kristina E. Rudd and Coauthors

JAMA | Original Investigation, June 5, 2018

Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis

Idris V. R. Evans and Coauthors

JAMA | Original Investigation, July 24/31, 2018

Bundled Strategies for the Care of Children With Presumed Sepsis

Robert J. Vinci and Elliot Melendez

JAMA | Editorial, July 24/31, 2018

Defining Pediatric Sepsis

Luregn J. Schlapbach and Niranjan Kissoon

JAMA Pediatrics | Viewpoint, April 2018

Enhancing Recovery From Sepsis: A Review

Hallie C. Prescott and Derek C. Angus

JAMA | Review, January 2, 2018

Postsepsis Morbidity

Hallie C. Prescott and Derek C. Angus

JAMA | JAMA Patient Page, January 2, 2018

Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014

Chanu Rhee and Coauthors

JAMA | Original Investigation, September 13, 2017

Counting Sepsis, an Imprecise but Improving Science

Kristina E. Rudd and Coauthors

JAMA | Editorial, September 13, 2017

Epidemiology of Sepsis Among Adolescents at Community Hospital Emergency Departments: Implications for Rory’s Regulations

Idris V. R. Evans and Coauthors

JAMA Pediatrics | Research Letter, August 14, 2017

In Treating Sepsis, Questions About Timing and Mandates

Jennifer Abbasi

JAMA | Medical News & Perspectives, August 8, 2017

Association Between US Norepinephrine Shortage and Mortality Among Patients With Septic Shock

Emily Vail and Coauthors

JAMA | Original Investigation, April 11, 2017

A Quantitative, Risk-Based Approach to the Management of Neonatal Early-Onset Sepsis

Michael W. Kuzniewicz and Coauthors

JAMA Pediatrics | Original Investigation, April 2017

Association Between Early Lactate Levels and 30-Day Mortality in Clinically Suspected Sepsis in Children

Halden F. Scott and Coauthors

JAMA Pediatrics | Original Investigation, March 2017

Management of Sepsis and Septic Shock

Michael D. Howell and Andrew M. Davis

JAMA | JAMA Clinical Guidelines Synopsis, February 28, 2017

Surviving Sepsis Guidelines: A Continuous Move Toward Better Care of Patients With Sepsis

Daniel De Backer and Todd Dorman

JAMA | Viewpoint, February 28, 2017

Proportion and Cost of Unplanned 30-Day Readmissions After Sepsis Compared With Other Medical Conditions

Florian B. Mayr and Coauthors

JAMA | Research Letter, February 7, 2017

Association Between Early Lactate Levels and 30-Day Mortality in Clinically Suspected Sepsis in Children

Halden F. Scott and Coauthors

JAMA Pediatrics | Original Investigation, January 9, 2017

Economic Evaluation of Quality Improvement Interventions for Bloodstream Infections Related to Central Catheters: A Systematic Review

Teryl K. Nuckols and Coauthors

JAMA Pediatrics | Review, December 2016

Act Fast and Think Sepsis

JAMA | News From the Centers for Disease Control and Prevention, October 11, 2016

Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis: The HYPRESS Randomized Clinical Trial

Didier Keh and Coauthors

JAMA | Original Investigation, October 3, 2016

Evaluating Glucocorticoids for Sepsis: Time to Change Course

Sachin Yende and B. Taylor Thompson

JAMA | Editorial, October 3, 2016

Will This Hemodynamically Unstable Patient Respond to a Bolus of Intravenous Fluids?

Peter Bentzer and Coauthors

JAMA | The Rational Clinical Examination, September 27, 2016

Practice Patterns and Outcomes Associated With Use of Anticoagulation Among Patients With Atrial Fibrillation During Sepsis

Allan J. Walkey and Coauthors

JAMA | Original Investigation, September 2016

Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock: A Randomized Clinical Trial

Frank Bloos and Coauthors

JAMA Internal Medicine | Original Investigation, July 18, 2016

Effect of a Primary Care Management Intervention on Mental Health–Related Quality of Life Among Survivors of Sepsis: A Randomized Clinical Trial

Konrad Schmidt and Coauthors

JAMA | Original Investigation, June 28, 2016

Standardized Rehabilitation and Hospital Length of Stay Among Patients With Acute Respiratory Failure: A Randomized Clinical Trial

Peter E. Morris and Coauthors

JAMA | Original Investigation, June 28, 2016

The Challenging Task of Improving the Recovery of ICU Survivors

Shannon L. Goddard and Neill K. J. Adhikari

JAMA | Editorial, June 28, 2016

Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis

Lonneke A. van Vught and Coauthors

JAMA | Original Investigation, March 15, 2016

Immunosuppression and Secondary Infection in Sepsis: Part, Not All, of the Story

Derek C. Angus and Steven Opal

JAMA | Editorial, March 15, 2016

Sepsis and the Global Burden of Disease in Children

Niranjan Kissoon and Timothy M. Uyeki

JAMA Pediatriacs | Viewpoint, February 2016

Assessment of a Central Line–Associated Bloodstream Infection Prevention Program in a Burn-Trauma Intensive Care Unit

Lois Remington and Coauthors

JAMA Surgery | Research Letter, December 23, 2015

Association of Intensive Care Unit Admission With Mortality Among Older Patients With Pneumonia

Thomas S. Valley and Coauthors

JAMA | Original Investigation, September 22/29, 2015

Septic Shock: Advances in Diagnosis and Treatment

Christopher W. Seymour and Matthew R. Rosengart

JAMA | Review, August 18, 2015

Readmission Diagnoses After Hospitalization for Severe Sepsis and Other Acute Medical Conditions

Hallie C. Prescott and Coauthors

JAMA | Research Letter, March 10, 2015

Lactate in Sepsis

Hernando Gomez and John A. Kellum

JAMA | JAMA Diagnostic Test Interpretation, January 13, 2015

Sepsis Mandates: Improving Inpatient Care While Advancing Quality Improvement

Colin R. Cooke and Theodore J. Iwashyna

JAMA | Viewpoint, October 8, 2014

Hospital Deaths in Patients With Sepsis From 2 Independent Cohorts

Vincent Liu and Coauthors

JAMA | Research Letter, July 2, 2014

Mortality Related to Severe Sepsis and Septic Shock Among Critically Ill Patients in Australia and New Zealand, 2000-2012

Kirsi-Maija Kaukonen and Coauthors

JAMA | Original Investigation, April 2, 2014

Declining Case Fatality Rates for Severe Sepsis: Good Data Bring Good News With Ambiguous Implications

Theodore J. Iwashyna and Derek C. Angus

JAMA | Editorial, April 2, 2014

Guideline Promotes Early, Aggressive Sepsis Treatment to Boost Survival

Bridget M. Kuehn

JAMA | Medical News and Perspectives, March 13, 2013

Effect of Empirical Treatment With Moxifloxacin and Meropenem vs Meropenem on Sepsis-Related Organ Dysfunction in Patients With Severe Sepsis: A Randomized Trial

Frank M. Brunkhorst and Coauthors

JAMA | Original Contribution, June 13, 2012

Management of Sepsis: A 47-Year-Old Woman With an Indwelling Intravenous Catheter and Sepsis

Derek C. Angus

JAMA | Clinical Crossroads, April 13, 2011

Serial Evaluation of the SOFA Score to Predict Outcome in Critically Ill Patients

Flavio Lopes Ferreira and Coauthors

JAMA | Caring for the Critically Ill Patient, October 10, 2001

Consensus Definitions for Sepsis and Septic Shock from JAMA Network (2024)

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